[英文释义] The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair,in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair,in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair,in which the primary lesions are not repaired,but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as dark repair because they do not require light.
Serial studies on relationship between nucleotide excision repair system gene expression and chemotherapeutic 核苷酸切除修复系统基因表达水平与化疗药物耐药相关性的系列研究
Pol p is normally regarded as the base excision repair ( ber ) polymerase . its role in ber is un-replaceable and thereby is important in mammalian genomic stability pci6在单碱基切除修复(baseexcisionfpair,ber)起到不可替代的重要作用,因此认为poip是参与维持细胞遗传稳定性的细胞内因子。